From: DSNurse@aol.com

Subject: Du Chemical response---as usual pass to others and act

Date: Jan 22, 2006 12:39 AM


It is indeed interesting that it is the French performing these studies! (see article below) Remember DU is not just a radiation issue but a chemical issue also.
I am asking gulf war vets please speak up! Let us know if you have been diagnosed with cancer and if it was found by VA or civilian drs. How many have been turned down by VA when you filed a claim.
Veterans please notice I am posting research from animals. We need you to identify yourself if you are having this problem. Only thru unified action will we get what is needed. You need to let us know but you also need to be writing your senators, reps, the RAC and also go to the newspapers. It is only through numbers that we will get people in DC to act and it takes all of us working together as veterans to make it happen!

DSNurse


1: Proteomics. 2005 Nov;5(17):4568-80. Related Articles, Links

Proteomic analysis of the response of human lung cells to uranium.

Malard V, Prat O, Darrouzet E, Berenguer F, Sage N, Quemeneur E.

Service de Biochimie post-genomique et Toxicologie Nucleaire, DSV/DIEP, CEA VALRHO, Bagnols-sur-Ceze, France. veronique.malard@cea.fr

The industrial use of uranium and particularly of depleted uranium, has pinpointed the need to review its chemical impact on human health. A proteomic approach was used to evaluate the response of a human lung cell line (A549) to uranium. We established the first 2-D reference map of the A549 cell line, identifying 87 spots corresponding to 81 major proteins. Uranium treatment triggered differential expression of 18 spots, of which 14 corresponded to fragments of cytokeratin 8 (CK8) and cytokeratin (CK18) and 1 to peroxiredoxin 1. We probed several hypotheses regarding CK cleavage, and observed that it did not result from caspase or calpain activity. Furthermore, we showed that the fragments are recognised by an anti-ubiquitin antibody (KM691). These results suggest a regulatory pathway involving CK ubiquitinylation or dysfunction in the proteasome-ubiquitin system in response to uranium exposure in human lung cells.

PMID: 16240288 [PubMed - in process]

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