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GULF WAR CANCERS |
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[email protected] Subject: About the Cancers for Gulf War-ODS---please all pass on to everyone Date: Jan 22, 2006 12:20 AM Letter sent to RAC concerning this. Need other vets writing letters to RAC and their Senators and reps. Please unless we have a unified effort nothing is going to happen! WE need the true Cancer data for GW1 vets!!! Not just VA Data but national cancer data and tumor registry data from every civilian hospital. Please help us get this done by including in the RAC report! WE need this as a reccommendation! It is 15 yrs post war and we the veterans of the gulf war deserve this collecting of cancer data. We also need the true death count!!! We need the Social security number match up I was told by OSGWI staffer that would never be done. Please help us get to the truth dont just believe the VA data because many vets still have not gone to the VA and besides with no presumptive diseases if they were diagnosed with cancer they aint wasting time fighting with the VA for a non existent benefit. See below: 1: was followed by the development of leukemias in 76% of all mice implanted with DU pellets. In contrast, only 12% of control mice developed leukemia. Results from our laboratory have also shown that DU is genotoxic and mutagenic in cultured human cells. Internalized DU could be a carcinogenic risk and concurrent alpha particle and heavy metal toxic effects complicate this potential risk Mol Cell Biochem. 2005 Nov;279(1-2):97-104. Related Articles, Links Miller AC, Bonait-Pellie C, Merlot RF, Michel J, Stewart M, Lison PD. Applied Cellular Radiobiology Department, Armed Forces Radiobiology Research, Institute, Bethesda, Maryland, USA. Depleted uranium (DU) is a dense heavy metal used in military applications. During military conflicts, US military personnel have been wounded by DU shrapnel. The health effects of embedded DU are unknown. Published data from our laboratory demonstrated that DU exposure in vitro can transform immortalized human osteoblast cells (HOS) to the tumorigenic phenotype. Results from our laboratory have also shown that DU is genotoxic and mutagenic in cultured human cells. Internalized DU could be a carcinogenic risk and concurrent alpha particle and heavy metal toxic effects complicate this potential risk. Anecdotal reports have suggested that DU can cause leukemia. To better assess this risk, we have developed an in vivo leukemogenesis model. This model involves using murine hematopoietic cells (FDC-P1) that are dependent on stimulation by granulocyte-macrophage colony stimulating factor (GM-CSF) or interleukin 3 (IL-3) and injected into mice to produce myeloid leukemia. Although immortalized, these cells are not tumorigenic on subcutaneous inoculation in mice. Intravenous injection of FDC-P1 cells into DU-implanted DBA/2 mice was followed by the development of leukemias in 76% of all mice implanted with DU pellets. In contrast, only 12% of control mice developed leukemia. Karyotypic analysis confirmed that the leukemias originated from FDC-P1 cells. The growth properties of leukemic cells from bone marrow, spleen, and lymph node were assessed and indicate that the FDC-P1 cells had become transformed in vivo. The kidney, spleen, bone marrow, muscle, and urine showed significant elevations in tissue uranium levels prior to induction of leukemia. These results demonstrated that a DU altered in vivo environment may be involved in the pathogenesis of DU induced leukemia in an animal model. |